Have You Heard Of Assisted Hatching?
In vitro fertilization (IVF) is an effective form of reproductive treatment that many couples turn to for infertility. Each IVF cycle is not guaranteed, and patients often need multiple cycles to achieve pregnancy. Fertility clinics are constantly looking for ways to improve IVF outcomes, and many have landed on assisted hatching for improved implantation. Assisted hatching is a laboratory technique used by embryologists to help embryos implant in the uterus. The process creates an opening in the zona pellucida, the protective outer layer of the embryo. Improving implantation is an effective way to boost the chances of success.
How does assisted hatching work?
During IVF, sperm and eggs are combined in a lab to create embryos. The embryo is then medically implanted into the uterus for pregnancy. During this process, the embryo naturally hatches from the zona pellucida shell before implantation. Scientists have discovered that some embryos fail to break through the shell, leading to a potentially failed implantation. With assisted hatching, the embryologist uses a laser or a chemical solution to create a small opening in the shell. This is usually done between the 3rd and 5th day of embryo development.
Does it help or hurt IVF?
Assisted hatching has been around for over 30 years but is not a practice performed by all fertility clinics. Proponents of the technique believe that assisted hatching improves implantation rates. Some studies have shown that laser-assisted hatching may improve pregnancy and live birth rates. Research continues to show favorable results. However, some scientists and fertility specialists believe that assisted hatching does not significantly improve outcomes. The results of other studies are mixed or inconclusive. Some risks could hinder IVF success. For instance, there is a small chance that breaking the shell can introduce contaminants or damage embryo cells, affecting long-term development.
Who can benefit from assisted hatching?
Assisted hatching may split opinions. However, some specific individuals can benefit from this process. Women or couples with multiple failed IVF cycles can try assisted hatching to improve outcomes. This strategy may be the game-changer for finally achieving pregnancy. Women over 37 or those with recently thawed embryos should consider assisted hatching. A diminished ovarian reserve may produce eggs or embryos that need additional support. These embryos may have a tougher outer shell, making breaking through difficult. Assisted hatching can be effective during IVF but must be discussed with the fertility clinic to minimize risk.
Try these implantation strategies
Assisted reproductive technology (ART) like IVF has created other strategies to help the implantation process. Some of these can be combined with assisted hatching to increase IVF success further. For instance, preimplantation genetic testing (PGT) is a screening technique to find chromosomal abnormalities and other challenges before transfer. Finding the best embryos may reduce the need for assisted hatching. Some doctors try to improve the uterine lining. An endometrial receptivity analysis (ERA) can determine the best time for transfer. Strategies like endometrial scratching, embryo glue, or removing fibroids can improve implantation rates. Hormone medication for severe cases, along with general lifestyle changes, can help.
Changing the implantation game
Failed implantations can delay IVF, leading to patient frustration and sadness. While there is no guarantee a single embryo will implant, some strategies that can help. Individuals with repeated failures, advanced reproductive age, or frozen-thawed embryos can use assisted hatching to help improve outcomes. While there is still room for research, the initial signs say this strategy can help. Combined with other implantation methods, the possibility of pregnancy is around the corner.
